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  Indian J Med Microbiol
 

Figure 3: Granulocyte colony-stimulating factor and capsaicin mobilize hematopoietic stem cells by activating nociceptors in bone marrow. Granulocyte colony-stimulating factor and capsaicin stimulate nociceptors to release calcitonin-gene-related peptide and activates the downstream Gas–adenylyl cyclase–cAMP signaling through receptor (RAMP1/CALCRL) to promote hematopoietic stem cell mobilization.

Figure 3: Granulocyte colony-stimulating factor and capsaicin mobilize hematopoietic stem cells by activating nociceptors in bone marrow. Granulocyte colony-stimulating factor and capsaicin stimulate nociceptors to release calcitonin-gene-related peptide and activates the downstream Ga<sub>s</sub>–adenylyl cyclase–cAMP signaling through receptor (RAMP1/CALCRL) to promote hematopoietic stem cell mobilization.