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  Indian J Med Microbiol
 

Figure 2: A lot of metastatic factors and cytokines secreted in the tumor microenvironment can trigger various metastatic signal pathways most of them can be suppressed by Raf kinase inhibitory protein via associating with upstream signal molecules as indicated. According to what has been observed in the tetradecanoyl-phorbol-13-acetate-triggered pathway that activates mitogen-activated protein kinase through mitochondria reactive oxygen species-mediated heat shock protein 60 oxidation, Raf kinase inhibitory protein may be released upon oxidation of critical upstream signal molecules resulting in reactivation of downstream signaling for tumor progression. Solid lines: established pathway. Dashed line: a proposed pathway

Figure 2: A lot of metastatic factors and cytokines secreted in the tumor microenvironment can trigger various metastatic signal pathways most of them can be suppressed by Raf kinase inhibitory protein via associating with upstream signal molecules as indicated. According to what has been observed in the tetradecanoyl-phorbol-13-acetate-triggered pathway that activates mitogen-activated protein kinase through mitochondria reactive oxygen species-mediated heat shock protein 60 oxidation, Raf kinase inhibitory protein may be released upon oxidation of critical upstream signal molecules resulting in reactivation of downstream signaling for tumor progression. Solid lines: established pathway. Dashed line: a proposed pathway