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  Indian J Med Microbiol
 

Figure 3: Impact of melatonin combined with sorafenib on cell migration and invasion in human renal cell carcinoma cells cells. Caki-1 and ACHN cells were treated with melatonin (4 mM), or both melatonin (4 mM) and Sorafenib (2.5 and 5 μM) for 24 h. The cell migrated numbers was detected by using cell migration and matrigel-based invasion assay. The numbers of migrate or invaded cell were counted, and shown in the histogram in the lower panel. These data are presented as the mean ± standard deviation of three independent experiments. **P < 0.01 in comparison to the control cells. #P < 0.01 in comparison to the melatonin-treated cell

Figure 3: Impact of melatonin combined with sorafenib on cell migration and invasion in human renal cell carcinoma cells cells. Caki-1 and ACHN cells were treated with melatonin (4 mM), or both melatonin (4 mM) and Sorafenib (2.5 and 5 μM) for 24 h. The cell migrated numbers was detected by using cell migration and matrigel-based invasion assay. The numbers of migrate or invaded cell were counted, and shown in the histogram in the lower panel. These data are presented as the mean ± standard deviation of three independent experiments. **<i>P</i> < 0.01 in comparison to the control cells. <sup>#</sup><i>P</i> < 0.01 in comparison to the melatonin-treated cell