Tzu Chi Medical Journal

REVIEW ARTICLE
Year
: 2021  |  Volume : 33  |  Issue : 4  |  Page : 317--322

Indocyanine green: An old drug with novel applications


Chia-Hung Lu1, Jong-Kai Hsiao2 
1 Department of Medical Imaging, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan
2 Department of Medical Imaging, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei; School of Medicine, Tzu Chi University, Hualien, Taiwan

Correspondence Address:
Jong-Kai Hsiao
Department of Medical Imaging, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 289, Jianguo Road, Xindian District, New Taipei
Taiwan

Indocyanine green (ICG), a US Food and Drug Administration-approved fluorescent compound, has been on the medical stage for more than 60 years. Current uses include hepatic function evaluation before surgical procedure and fundus evaluation. The large safety margin and near-infrared fluorescent optical advantage of the drug have proved useful in several clinical trials of intraoperative systems for tumor removal. Several nanoparticle-sized formulations for thermal ablation and photodynamic therapy have also been evaluated in animal experiments. Studies have attempted to manipulate ICG as a reporter fluorophore with initial success. In this article, we reviewed ICG's histological applications, chemical and physical properties, current clinical applications, ongoing clinical trials, and biomedical studies and prospects. We believe that ICG could be used with novel biotechnological techniques, such as fluorescent endoscopy and photoacoustic equipment, in a range of biomedical fields.


How to cite this article:
Lu CH, Hsiao JK. Indocyanine green: An old drug with novel applications.Tzu Chi Med J 2021;33:317-322


How to cite this URL:
Lu CH, Hsiao JK. Indocyanine green: An old drug with novel applications. Tzu Chi Med J [serial online] 2021 [cited 2021 Dec 9 ];33:317-322
Available from: https://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=317;epage=322;aulast=Lu;type=0