Tzu Chi Medical Journal

REVIEW ARTICLE
Year
: 2018  |  Volume : 30  |  Issue : 1  |  Page : 1--4

Evidence-based review and appraisal of the use of droperidol in the emergency department


Pei-Chun Lai1, Yen-Ta Huang2 
1 Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation; School of Medicine, Tzu Chi University, Hualien, Taiwan
2 Division of Experimental Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation; Department of Pharmacology, Tzu Chi University, Hualien, Taiwan

Correspondence Address:
Dr. Yen-Ta Huang
Division of Experimental Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation, 707, Section 3, Chung-Yang Road, Hualien
Taiwan

Droperidol is a short-acting, potent dopamine D2 antagonist that can pass through the blood–brain barrier. A black box warning was issued for droperidol by the United States Food and Drug Administration in 2001 because of a risk of development of torsades de pointes induced by QT prolongation. Many experts feel that the incidence of arrhythmia is overestimated, and low-dose droperidol is almost always used by anesthesiologists for postoperative nausea and vomiting. In this review, we used evidence-based analysis to appraise high-quality studies with a low risk of bias published after 2001 on the use of droperidol in the emergency department (ED). Droperidol appears not only efficacious but also safe to treat patients with nausea/vomiting, acute psychosis, and migraine in the ED. For these conditions, droperidol may be an option for shared decision-making.


How to cite this article:
Lai PC, Huang YT. Evidence-based review and appraisal of the use of droperidol in the emergency department.Tzu Chi Med J 2018;30:1-4


How to cite this URL:
Lai PC, Huang YT. Evidence-based review and appraisal of the use of droperidol in the emergency department. Tzu Chi Med J [serial online] 2018 [cited 2021 Dec 1 ];30:1-4
Available from: https://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=1;spage=1;epage=4;aulast=Lai;type=0